Gather the ingredients including Chex cereal (rice, corn, and/or wheat), pretzels, mixed nuts, butter, Worcestershire sauce, garlic powder, onion powder, seasoned salt, and optional ingredients like bagel chips or cheese crackers.
Preheat your oven to 250°F (120°C) and line a large baking sheet with parchment paper or aluminum foil.
In a large mixing bowl, combine the Chex cereal, pretzels, mixed nuts, and any other dry ingredients you're using, and mix them together evenly.
Melt the butter in a small saucepan over low heat. Once melted, stir in the Worcestershire sauce, garlic powder, onion powder, and seasoned salt until well combined.
Pour the melted butter mixture over the dry ingredients in the mixing bowl. Use a spatula or large spoon to gently toss and coat all the dry ingredients evenly with the seasoned butter mixture.
Spread the coated mixture evenly onto the prepared baking sheet in a single layer. Bake in the preheated oven for about 1 hour, stirring every 15 minutes to ensure even baking and prevent burning.
Once the Chex mix is golden brown and crisp, remove it from the oven and let it cool completely on the baking sheet. It will continue to crisp up as it cools.
Once cooled, transfer the Chex mix to an airtight container or resealable bag for storage. Enjoy it as a tasty snack or party treat, and store any leftovers for later consumption.